生活休闲_医药类课件PPT模板.ppt 14页

'【般若黑洞】出品NorthwesternPolytechnicUniversity基于大分子的药物控释肿瘤靶向PolymericTumor-TargetingDrugControlledRelease DrugLoad装载定位TargetingDrugRelease释放 胶束Micelles树枝状聚合物DendrimersLiposomes微脂囊聚合物-药物偶联物Polymer-drugconjugatesDrugLoad装载 定位主动active被动passiveTargeting配合基-受体Ligand-receptorEPR效应EPREffect叶酸cRGD 正常组织癌变部位 DrugRelease释放pH温度降解磁场UV电场内因外因PDEAEMAPNIPAM-s-s-hydrazonebonds 多层分子设计MolecularDesign嵌段分子量端基ATRPRAFT点击化学超分子星形开环 Tumor-TargetingPeptideConjugatedpH-ResponsiveMicellesasaPotentialDrugCarrierforCancerTherapyXiangLanWu,JongHoKim Tumor-Targeting,pH-Responsive,andStableUnimolecularMicellesasDrugNanocarriersforTargetedCancerTherapyXiaoqiangYang,JamisonJ.Grailer,SrikanthPilla PEG-SS-PPS:Reduction-SensitiveDisulfideBlockCopolymerVesiclesforIntracellularDrugDeliveryXiangLanWu,JongHoKim Folate-ConjugatedThermoresponsiveBlockCopolymers:HighlyEfficientConjugationandSolutionSelf-AssemblyPriyadarsiDe,SudershanR.Gondi,andBrentS.Sumerlin Developmentofmultiple-layerpolymericparticlesfortargetedandcontrolleddrugdeliveryBhanuprasanthKoppolu,MS,MahamRahim, OSiOSiOSiSiOSiOSiSiOSiOSiOSiOSiHSiOSiOSiHOSiOSiHSiOSiHNH2NHNH2NHNH2NHNNH2graftedPNIPAMShellβ-CDbasedHBPCoreThermo-ResponsiveHyperbranchedpoly(β-CD)s-g-PNIPAM Thankyou!PolymericTumor-TargetingDrugControlledReleaseNorthwesternPolytechnicUniversity'